Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons (Original Article, N Engl J Med 2021;384:2273-2282). In the Results section of the Abstract (page 2273), the third sentence should have read, “Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) were pregnancy losses and 712 (86.1%) were live births (mostly among participants vaccinated in the third trimester),” rather than “…of which 115 (13.9%) resulted in a pregnancy loss and 712 (86.1%) resulted in a live birth (mostly among participants with vaccination in the third trimester).” In the first paragraph of the Discussion section (page 2277), the parenthetical in the third sentence should have begun, “(i.e., preterm birth, small size, …,” rather than “(e.g., fetal loss, preterm birth, small size, ….” In Table 4 (page 2280), the double dagger symbol in the Spontaneous abortion row should have followed “Spontaneous abortion: <20 wk^15-17.” The “Published Incidence” cell in the same row should have read “Not applicable,” rather than “10–26,” and the “V-safe Pregnancy Registry” cell should have read “104,” rather than “104/827 (12.6)‡.” In the table footnotes, the following content should have been appended to the double dagger footnote: “No denominator was available to calculate a risk estimate for spontaneous abortions, because at the time of this report, follow-up through 20 weeks was not yet available for 905 of the 1224 participants vaccinated within 30 days before the first day of the last menstrual period or in the first trimester. Furthermore, any risk estimate would need to account for gestational week–specific risk of spontaneous abortion.” The article is correct at NEJM.org.