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The Key Role of Epigenetics in Human Disease Prevention and Mitigation

List of authors.
  • Andrew P. Feinberg, M.D., M.P.H.

Epigenetics is the regulation of gene expression through alterations in DNA or associated factors (other than the DNA sequence). These factors control the diverse manifestations of diseases. Insights into epigenetic modification may lead to new therapies for common diseases.

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Funding and Disclosures

Disclosure forms provided by the author are available with the full text of this article at NEJM.org.

I thank Michael Koldobskiy, Tomas Ekstrom, Anita Gondor, Yun Liu, Lindsay Rizzardi, and Xin Li for critical reading and suggestions.

Author Affiliations

From the Department of Medicine, Johns Hopkins University School of Medicine, the Department of Biomedical Engineering, Whiting School of Engineering, and the Department of Mental Health, Johns Hopkins Bloomberg School of Public Health — all in Baltimore.

Address reprint requests to Dr. Feinberg at the Department of Medicine, Johns Hopkins University School of Medicine, 855 N. Wolfe St., Rangos 570, Baltimore, MD, or at .

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