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Review ArticleMedical ProgressFree Preview

Focal Segmental Glomerulosclerosis

List of authors.
  • Vivette D. D'Agati, M.D.,
  • Frederick J. Kaskel, M.D., Ph.D.,
  • and Ronald J. Falk, M.D.

Focal segmental glomerulosclerosis, which is characterized by progressive glomerular scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in adults. This review considers current approaches to diagnosis and management of the disease.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

No potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Department of Pathology, Columbia University College of Physicians and Surgeons (V.D.D.); and the Division of Pediatric Nephrology, Albert Einstein College of Medicine (F.J.K.) — both in New York; and UNC Kidney Center and the Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill (R.J.F.).

Address reprint requests to Dr. D'Agati at Columbia University Medical Center, Division of Renal Pathology, Rm. VC14-224, 630 W. 168th St., New York, NY 10032, or at .

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