Genomewide Association Studies and Human Disease

John Hardy, Ph.D.,
and Andrew Singleton, Ph.D.

Genomewide association studies have uncovered many genetic variants that confer susceptibility to disease. This article describes the genomewide association study and new approaches that may address some of its limitations.

Funding and Disclosures

Supported in part by the Intramural Research Program of the National Institute on Aging of the National Institutes of Health (project number, 1-Z01-AG000949-02) and by the Medical Research Council.

No potential conflict of interest relevant to this article was reported.

This article (10.1056/NEJMra0808700) was published at NEJM.org on April 15, 2009.

We thank Dr. Katrina Gwinn for her constructive comments on the manuscript.

Author Affiliations

From the Institute of Neurology, University College London, London (J.H.); and the Laboratory of Neurogenetics, Bethesda, MD (A.S.).

Address reprint requests to Dr. Hardy at the Institute of Neurology, University College London, Queen Sq., London WC1N 3BG, United Kingdom, or at [email protected].

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