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Review ArticleMechanisms of DiseaseFree Preview

Endometriosis

List of authors.
  • Serdar E. Bulun, M.D.

This review emphasizes the participation of estrogen and inflammation in the development of endometriosis. A feedback cycle in which prostaglandins and aromatase activity are prominent allows for the persistence of endometriotic tissue. Knowledge of this cycle has important implications for the treatment of endometriosis.

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Funding and Disclosures

Supported in part by grants from the National Institutes of Health (HD38691 and HD40093) and from the Friends of Prentice.

Dr. Bulun reports receiving consultation fees from Meditrina Pharmaceuticals, GlaxoSmithKline, and Novartis. No other potential conflict of interest relevant to this article was reported.

I thank Dr. Sherman Elias for helpful discussions.

Author Affiliations

From the Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago.

Address reprint requests to Dr. Bulun at the Division of Reproductive Biology Research, Dept. of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, 303 E. Superior St., Rm. 4-123, Chicago, IL 60611, or at .

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