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A correction has been published 1 2

Review ArticleDrug TherapyFree Preview

Hepatitis B Virus Infection

List of authors.
  • Jules L. Dienstag, M.D.

More effective and less resistance-prone antiviral agents are now available to treat hepatitis B virus (HBV) infection. Profound, durable, therapeutic HBV DNA suppression to slow and reverse the progression of chronic HBV infection is important, given the evidence linking high-level HBV replication and the late consequences of chronic HBV infection. This article reviews strategies for treating HBV infection.

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Funding and Disclosures

Dr. Dienstag reports serving as a member of scientific advisory boards for Vertex Pharmaceuticals, Bristol-Myers Squibb, Gilead Sciences, Metabasis, SciClone, and Nucleonics and as an ad hoc consultant for Achillion Pharmaceuticals, Amgen, Biogen, Cubist Pharmaceuticals, Oxxon Therapeutics, CombinatoRx, Pharmasset, Wyeth, ViroPharma, AstraZeneca, and Avant Immunotherapeutics; receiving research support from Vertex; holding stock options from Achillion Pharmaceuticals, Metabasis, and Nucleonics; and serving on clinical trial data monitoring and adjudication committees for Schering-Plough Research Institute, Genzyme, Human Genome Sciences, and Gilead Sciences. No other potential conflict of interest relevant to this article was reported.

This article (10.1056/NEJMra0801644) was updated on July 14, 2010, at NEJM.org.

Author Affiliations

From the Gastrointestinal Unit (Medical Services), Massachusetts General Hospital; and the Department of Medicine and Office of the Dean for Medical Education, Harvard Medical School — both in Boston.

Address reprint requests to Dr. Dienstag at the Gastrointestinal Unit, Jackson 7, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, or at .

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