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Review ArticleMechanisms of DiseaseFree Preview

Medium- and Large-Vessel Vasculitis

List of authors.
  • Cornelia M. Weyand, M.D., Ph.D.,
  • and Jörg J. Goronzy, M.D., Ph.D.

Giant-cell arteritis typically involves extracranial branches of the aorta, such as the temporal and vertebral arteries. Temporal arteritis and polymyalgia rheumatica often coexist, and systemic manifestations of inflammation occur in virtually all forms of giant-cell arteritis. This article reviews the mechanisms that contribute to the causes of giant-cell arteritis, with an emphasis on immune-mediated injury to arteries.

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Funding and Disclosures

Supported by grants from the National Institutes of Health (R01 EY11916 and R01 HL63919) and by the Mayo Foundation.

Author Affiliations

From the Departments of Medicine and Immunology, Mayo Clinic, Rochester, Minn.

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