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Review ArticleMechanisms of DiseaseFree Preview

The Chromogranin–Secretogranin Family

List of authors.
  • Laurent Taupenot, Ph.D.,
  • Kimberly L. Harper, M.D.,
  • and Daniel T. O'Connor, M.D.

The members of the chromogranin–secretogranin family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons. These granins, the chief of which is chromogranin A, participate in sympathoadrenal activity and serve as markers of neuroendocrine tumors, especially pheochromocytoma.

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Funding and Disclosures

Supported by grants from the National Institutes of Health (DK59628, to Dr. Taupenot, and HL58120 and HL69758, to Dr. O'Connor) and the Department of Veterans Affairs (to Dr. O'Connor).

We are indebted to Drs. Peter E. Cadman, Bruce M. Gill, Vivian Y. Hook, Qijiao Jiang, Mala T. Kailasam, Brian P. Kennedy, Nitish R. Mahapatra, Manjula Mahata, Sushil K. Mahata, Robert J. Parmer, Fangwen Rao, David J. Rozansky, Mats Stridsberg, Marwan A. Takiyyuddin, Kechun Tang, Carolyn V. Livsey-Taylor, Hongjiang Wu, Sukkid Yasothornsrikul, Noboru Yanaihara, and Michael G. Ziegler for their collaboration, and to Dr. Åsa Thureson-Klein for the electron micrograph of chromogranin A in chromaffin granules of the adrenal medulla.

Author Affiliations

From the Department of Medicine (L.T., K.L.H., D.T.O.) and the Center for Molecular Genetics (D.T.O.), University of California at San Diego, La Jolla; and the Veterans Affairs San Diego Healthcare System, San Diego, Calif. (L.T., K.L.H., D.T.O.).

Address reprint requests to Dr. O'Connor at the Department of Medicine (9111H), University of California at San Diego, 3350 La Jolla Village Dr., San Diego, CA 92161, or at .

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