Molecular Characteristics of Diffuse Large-B-Cell Lymphoma

The utility of disease classifications depends greatly on the tools used. The lower the resolving power, the more subjective and controversial the interpretation. As has been the case throughout the history of lymphoma taxonomy, this often leads to a plethora of classification schemes, with resultant confusion and miscommunication. Yet diagnostic precision is an essential foundation for effective therapy, since individual diseases might be expected, in general, to require individual therapeutic approaches. Unfortunately, in the field of cancer, the weaknesses inherent in a purely histologic diagnosis, the primary classification tool used for most of the 20th century, have often led to . . .