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Generalized Anxiety Disorder

List of authors.
  • Murray B. Stein, M.D., M.P.H.,
  • and Jitender Sareen, M.D.

Persistent anxiety and uncontrollable worry for at least 6 months characterize generalized anxiety disorder. First-line treatments are cognitive behavioral therapy or pharmacotherapy with a selective serotonin-reuptake or serotonin–norepinephrine reuptake inhibitor.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Stein reports receiving consulting fees from Janssen, Pfizer, and Tonix Pharmaceuticals, and from Care Management Technologies for providing a review of health service protocols. No other potential conflict of interest relevant to this article was reported.

We thank Yunqiao Wang, M.A., for assistance with the preparation of an earlier version of the manuscript.

Author Affiliations

From the Department of Psychiatry and the Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, and the Veterans Affairs San Diego Healthcare System, San Diego — both in California (M.B.S.); and the Departments of Psychiatry, Psychology, and Community Health Sciences, University of Manitoba, Winnipeg, Canada (J.S.).

Address reprint requests to Dr. Stein at the University of California, San Diego, 9500 Gilman Dr., Mail Code 0855, La Jolla, CA 92093-0855, or at .

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