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Clinical PracticeFree Preview

Resistant or Difficult-to-Control Hypertension

List of authors.
  • Marvin Moser, M.D.,
  • and John F. Setaro, M.D.

A 70-year-old woman with a long-standing history of hypertension comes for follow-up. Her medications include atenolol (100 mg daily), hydrochlorothiazide (12.5 mg daily), lisinopril (40 mg daily), and ibuprofen (400 mg twice daily for osteoarthritis). She does not smoke or drink alcohol. Her body-mass index is 32. Her blood pressure (measured three times while she is seated) ranges from 164/92 to 170/96 mm Hg; her pulse rate is 72 per minute. Examination of her ocular fundi reveals arteriolar narrowing. The results of cardiovascular examination are normal. How should she be further evaluated and treated?

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Funding and Disclosures

Dr. Moser reports having received consulting and lecture fees from AstraZeneca; and Dr. Setaro, lecture fees from Sanofi-Aventis, Boehringer-Ingelheim, and Abbott, and research support from Bristol-Myers Squibb. No other potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Section of Cardiovascular Medicine and the Cardiovascular Disease Prevention Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.

Address reprint requests to Dr. Moser at the Section of Cardiovascular Medicine, Yale University School of Medicine, Box 208017, 333 Cedar St., New Haven, CT 06520.

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