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Clinical Implications of Basic ResearchFree Preview

Prime Time for Genome Editing?

Fyodor D. Urnov, Ph.D.

Protein engineering has yielded a new, potent tool — in the form of a chimeric enzyme — for correcting genetic mutations. Proof of principle that this enzyme can correct different types of mutation, and even combinations of mutations, has been obtained in different types of mammalian cells.

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Funding and Disclosures

Disclosure forms provided by the author are available at NEJM.org.

Author Affiliations

From the Innovative Genomics Institute and the University of California, Berkeley.

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