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Clinical Implications of Basic ResearchFree Preview

Metabolism, Gliomas, and IDH1

List of authors.
  • Jan Smeitink, M.D., Ph.D.

A mutation in IDH1, which encodes an isocitrate dehydrogenase, is associated with susceptibility to glioma. This mutation results in an acquired enzyme activity that points to a potential biomarker of the mutant tumor.

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Funding and Disclosures

Disclosure forms provided by the author are available with the full text of this article at NEJM.org.

Author Affiliations

From the Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.

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