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Brain Changes in Response to Long Antarctic Expeditions

Brain imaging in eight polar expeditioners before and after 14 months of isolation showed that the volume of the hippocampal dentate gyrus was lower than that in controls. This may reflect the effects on the brain of prolonged social and environmental deprivation.

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Alexander C. Stahn, Ph.D.
Hanns-Christian Gunga, M.D.
Charité–Universitätsmedizin Berlin, Berlin, Germany

Eberhard Kohlberg, M.D.
Alfred-Wegener-Institut, Bremerhaven, Germany

Jürgen Gallinat, M.D.
University Medical Center Hamburg–Eppendorf, Hamburg, Germany

David F. Dinges, Ph.D.
University of Pennsylvania, Philadelphia, PA

Simone Kühn, Ph.D.
Max Planck Institute for Human Development, Berlin, Germany

Funding and Disclosures

Supported by grants (50WB1330 and 50WB1525) from the German Aerospace Center.

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

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