Skip to main content
Device Global Header

Subscribe
or Renew

Advanced Search

This article is available to subscribers. Subscribe now. Already have an account? Sign in

CorrespondenceFree Preview

Pertactin-Negative Variants of Bordetella pertussis in the United States

In 12 B. pertussis isolates from children in Philadelphia, 11 were negative for the pertactin antigen that is a component of the acellular vaccine. Such variants may reflect selection pressure from the vaccine and may reduce its effectiveness for preventing whooping cough.

Continue reading this article

Select an option below:

Create your account to get 2 free subscriber-only articles each month.

Get Free Access Now Subscribe For Full Access

Already have an account?

Sign In

Print subscriber?

Activate your online access.

Anne Marie Queenan, Ph.D.
Janssen Research and Development, Raritan, NJ

Pamela K. Cassiday, M.S.
Centers for Disease Control and Prevention, Atlanta, GA

Alan Evangelista, Ph.D.
St. Christopher's Hospital for Children, Philadelphia, PA

Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

Print Subscriber? Activate your online access.