C3 Polymorphisms and Outcomes of Renal Allografts

To the Editor: Varagunam et al. (Feb. 26 issue)¹ do not confirm the previously reported association between the complement component 3 (C3) SS genotype and worsened outcomes of renal transplantation.² However, the disparity in the results of these two studies may be due to differences in the proportion of recipients with specific risks of chronic allograft dysfunction. Moreover, the C3 SS genotype can be either a protective factor¹ or an exacerbating factor in the progression of endogenous kidney disease, and it varies according to the disorder. For example, the SS genotype is associated with accelerated progression of membranous nephropathy³ and . . .