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An Unusual Outbreak of Hypoglycemia

To the Editor: The off-label use of drugs for the enhancement of sexual performance in persons without erectile dysfunction is a phenomenon that is increasingly recognized.1 These drugs are available in illegal forms, including counterfeit versions of brand-name drugs for the treatment of erectile dysfunction and purported herbal remedies containing synthetic phosphodiesterase type 5 inhibitors.2 We describe an outbreak of severe hypoglycemia in Singapore; this outbreak was associated with contamination of illegal sexual-enhancement drugs with glyburide.Between January 1 and May 26, 2008, a total of 150 nondiabetic patients with severe hypoglycemia were admitted to the five public hospitals in . . .

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Shih Ling Kao, M.B., B.S., M.R.C.P.
National University Hospital, Singapore 119074, Singapore

Cheng Leng Chan, B.Sc. (Pharm.)
Belinda Tan, B.Sc. (Pharm.)
Health Sciences Authority, Singapore 138667, Singapore

C.C. Tchoyoson Lim, F.R.C.R., M.Med.
National Neuroscience Institute, Singapore 308433, Singapore

Rinkoo Dalan, M.R.C.P.
Tan Tock Seng Hospital, Singapore 308433, Singapore

Daphne Gardner, M.B., B.S., M.R.C.P.
Singapore General Hospital, Singapore 169608, Singapore

Edward Pratt, B.Sc., M.R.C.P.
Changi General Hospital, Singapore 529889, Singapore

Marilyn Lee, M.B., B.S., M.R.C.P.
Alexandra Hospital, Singapore 159964, Singapore

Kok Onn Lee, M.D.
National University Hospital, Singapore 119074, Singapore

Funding and Disclosures

We thank Min Yong Low, Health Sciences Authority, Singapore, for the chromatograms.

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