Gatifloxacin and Dysglycemia in Older Adults

To the Editor: Park-Wyllie and colleagues (March 30 issue)¹ advise avoiding the use of gatifloxacin because of the increased risk of dysglycemia, and they suggest using alternative antibiotics, including other fluoroquinolones, that confer little or no increased risk of dysglycemia. This suggestion must be questioned. Although it appears that the administration of moxifloxacin has no clinically relevant effect on blood glucose homeostasis,² other fluoroquinolones may trigger dysglycemic events, especially in patients with diabetes who receive sulfonylureas.³ Clinicians should be aware of the possibility of dysglycemic events in patients receiving fluoroquinolones. To the Editor: The article by Park-Wyllie et al. has . . .