Endoluminal Beta-Radiation Therapy for the Prevention of Coronary Restenosis after Balloon Angioplasty
List of authors.
Other members of the Dose-Finding Study Group are listed in the Appendix.
Abstract
Background
Beta radiation is effective in reducing vascular neointimal proliferation in animals after injury caused by balloon angioplasty. However, the lowest dose that can prevent restenosis after coronary angioplasty has yet to be determined.
Methods
After successful balloon angioplasty of a previously untreated coronary stenosis, 181 patients were randomly assigned to receive 9, 12, 15, or 18 Gy of radiation delivered by a centered yttrium-90 source. Adjunctive stenting was required in 28 percent of the patients. The primary end point was the minimal luminal diameter six months after treatment, as a function of the delivered dose of radiation.
Results
At the time of follow-up coronary angiography, the mean minimal luminal diameter was 1.67 mm in the 9-Gy group, 1.76 mm in the 12-Gy group, 1.83 mm in the 15-Gy group, and 1.97 mm in the 18-Gy group (P=0.06 for the comparison of 9 Gy with 18 Gy), resulting in restenosis rates of 29 percent, 21 percent, 16 percent, and 15 percent, respectively (P=0.14 for the comparison of 9 Gy with 18 Gy). At that time, 86 percent of the patients had had no serious cardiac events. In 130 patients treated with balloon angioplasty without a stent, restenosis rates were 28 percent, 17 percent, 16 percent, and 4 percent, respectively (P= 0.02 for the comparison of 9 Gy with 18 Gy). Among these patients, there was a dose-dependent enlargement of the lumen in 28 percent, 50 percent, 45 percent, and 74 percent of patients, respectively (P<0.001 for the comparison of 9 Gy with 18 Gy). The rate of repeated revascularization was 18 percent with 9 Gy and 6 percent with 18 Gy (P=0.26).
Conclusions
Intracoronary beta-radiation therapy produces a significant dose-dependent decrease in the rate of restenosis after angioplasty. An 18-Gy dose not only prevents the renarrowing of the lumen typically observed after successful balloon angioplasty, but actually induces luminal enlargement.
Methods
Study Design and Objectives
The study was designed as a prospective, randomized, multicenter, dose-finding trial. Between October 1997 and February 1999, 183 patients were enrolled in the trial at five European centers and randomly assigned by computer, over the telephone, to receive 9 Gy, 12 Gy, 15 Gy, or 18 Gy of radiation. Patients more than 50 years old who had angina pectoris or silent ischemia were enrolled if they were suitable candidates for the dilation of a previously untreated native coronary stenosis. For the enrollment criteria to be met, the diameter of the vessel had to be between 2.5 and 4.0 mm, and the stenosis had to be shorter than 15 mm. Patients also had to be eligible for angiographic and clinical follow-up at six months. Patients were deemed ineligible if they had had a recent myocardial infarction with abnormal base-line levels of cardiac enzymes, had a life expectancy of less than six months, were pregnant, had had cancer within the previous five years, had previously received mediastinal irradiation, or were currently participating in another trial. Written informed consent was obtained from all participating patients.
Irradiation was performed after the completion of the balloon angioplasty. The physicians performing the angioplasty were discouraged from using multiple balloon inflations and balloon displacements, so that the length of the vessel segment injured would be limited. Beta irradiation was not performed if there was an urgent need for stent implantation, if glycoprotein IIb/IIIa–receptor blockers had been administered, or if there was abrupt vessel closure that remained unresolved. Complementary stent implantation was allowed in cases in which there were extensive dissections, symptomatic reductions in blood flow, or both. Initially, ticlopidine and aspirin were given for two months after the procedure; starting in November 1998, the duration of treatment with these drugs was extended to seven months.
The primary end point of the study was the minimal luminal diameter at six months within the vessel treated by balloon angioplasty, as measured by quantitative coronary angiography, as a function of the delivered dose of beta radiation. The secondary end points were the incidences in the entire study population of the following serious cardiac events: death, myocardial infarction, percutaneous intervention in the target vessel (defined as any additional intervention within the treated vessel), and coronary-artery bypass grafting. Myocardial infarction was diagnosed when two of the following occurred: chest discomfort lasting at least 30 minutes, the development of abnormal new Q waves, and an increase in the level of creatine kinase or MB isoenzymes to more than twice the upper limit of normal.
Procedure for Radiation Therapy
The system used for intraarterial beta-radiation therapy has been described previously10-13; it consists of the yttrium-90 beta-ray–emitting source (half-life, 64 hours; maximal energy, 2.284 MeV), a centering balloon, and an automated delivery device. The radioactive source consists of a 29-mm-long, flexible coil, secured at the end of a 0.035-cm thrust wire between distal and proximal 6-mm-long, radiopaque tungsten markers, which allow precise localization of the source under fluoroscopy. The effective length of the vessel segment being irradiated (the 90 percent isodose line) is 24 mm. The centering balloon, consisting of four interconnected compartments, is designed to position the source wire centrally inside the coronary lumen, thereby contributing to a more homogeneous distribution of the dose of radiation along the vessel wall. Three radiopaque markers are located between the balloon compartments and allow the device to be positioned, with the use of fluoroscopy, at the exact site of the previous angioplasty. The centering balloon is inflated with 5 ml of carbon dioxide up to a maximal pressure of 4 atm. As compared with the use of contrast medium, the use of carbon dioxide permits faster inflation and deflation of the balloon and a shorter treatment time (because there is less attenuation of the radiation).11,12
The use of an automated delivery device ensured the safe storage of the source, its easy insertion and withdrawal, its accurate positioning, and the instantaneous calculation and delivery of the dose. At the end of each treatment, a printed report was automatically generated. After the completion of balloon angioplasty, the centering balloon, which had the same diameter as the angioplasty balloon, was positioned so that it would cover fully the site dilated by the angioplasty balloon. After the successful advancement and retrieval of a nonradioactive test wire, the yttrium-90 source was automatically advanced to the same site. This procedure was performed by a team composed of a cardiologist, an oncologist, and a medical physicist, who collaborated according to local practices and regulations. All teams applied the measures normally used in the interventional suite for protection from radiation.14
Angiographic Analysis
Coronary angiograms were obtained in multiple views after patients had received an intracoronary injection of nitrates. An independent core laboratory (Cardialysis, Rotterdam, the Netherlands), whose personnel were unaware of the dose of radiation associated with each angiogram, analyzed the angiograms quantitatively using edge-detection techniques.15 Coronary luminal diameter and degree of stenosis (as a percentage of the diameter) were measured before dilation, at the end of the procedure, and during follow-up angiography six months later (or earlier if there were recurrent symptoms). Restenosis was defined as the presence of stenosis of more than 50 percent of the luminal diameter. The loss in luminal diameter was calculated as the difference between the luminal diameter measured immediately after the procedure and that measured at six months. The entire irradiated segment of the vessel (24 mm long) and the edges of that segment (5 to 6 mm on each side of the segment) were analyzed. The resulting segment (34 to 36 mm long) encompassed the initial site of stenosis, the 20-mm segment injured by the angioplasty device, the 30-mm area affected by the centering balloon, and the immediately adjacent proximal and distal segments of the vessel (each 2 to 3 mm long). This method of analysis has been used in previous trials of vascular brachytherapy.15
Statistical Analysis
For a study with a power (1–β) of 90 percent, a one-sided type I error (α) of 0.05, and an expected minimal luminal diameter at follow-up of 1.67 mm (that achieved in the Benestent II trial5 among patients who underwent balloon angioplasty alone), with a standard deviation of 27.5 percent, we calculated that we had to enroll 34 patients in each group in order to detect a 20 percent improvement in the minimal luminal diameter at six months (2.00 vs. 1.67 mm). In order to account for an expected 30 percent rate of stent implantation, we increased the study population to 180 patients (45 in each of four groups).
For the comparison of binary variables, a Fisher's exact test for two groups was used, or the chi-square test was used when applicable. For the comparison of continuous variables, two-tailed Student's t-tests were used. The data are expressed as means ±SE.
Results
Patient Population
Table 1.
Table 1. Characteristics of the Patients. Of 183 patients who underwent randomization, 181 (mean age, 64±0.6 years; 74 percent male) received the prescribed doses of beta radiation: 45 received 9 Gy, 45 received 12 Gy, 46 received 15 Gy, and 45 received 18 Gy. Radiation therapy was not administered in two cases (in one due to a technical failure, and in one because the angioplasty was unsuccessful). There were no significant differences among the dose groups in terms of the demographic characteristics of the patients or the characteristics of the lesions (Table 1). Balloon angioplasty alone was performed in 130 patients (72 percent). Stent implantation following brachytherapy was required in 51 patients (in 47 percent of these patients because of residual stenosis of more than 50 percent of luminal diameter, and in the remainder because of major dissection).
Angiographic Results
Table 2.
Table 2. Angiographic Results Immediately after Balloon Angioplasty and at Six Months. The mean degree of stenosis before the angioplasty procedure, expressed as a percentage of the vessel diameter, was 65±1.5, 64±1.6, 66±1.3, and 65±1.7 in the 9-Gy, 12-Gy, 15-Gy, and 18-Gy groups, respectively. There were no significant differences among the groups in the mean degree of residual stenosis after balloon angioplasty or in the postprocedural minimal luminal diameter (Table 2). The mean duration of radiation treatment was 1.81±0.10, 2.55±0.20, 3.01± 0.16, and 3.17±0.19 minutes, respectively, in the four groups. Ten patients who were asymptomatic at six months declined to undergo a second catheterization; one patient died after having an acute myocardial infarction; and lung cancer was diagnosed in another patient. The full complement of angiograms was thus available for analysis in 169 patients; all three angiograms — preprocedural, postprocedural, and follow-up — were suitable for quantitative analysis in 168 of these patients.
Figure 1.
Figure 1. Loss in Minimal Luminal Diameter per Vessel Segment from Immediately after Angioplasty to Follow-up in the 168 Patients for Whom Angiographic Follow-up Data Were Available at Six Months. The mean (+SE) loss in minimal luminal diameter is shown for all patients in the four dose groups. The length of the vessel segment analyzed was progressively increased from the obstructed segment to include the injured segment, the irradiated segment plus the edges, and finally to the entire vessel (total). The loss decreased in a dose-dependent manner, and the greatest loss occurred in the irradiated area. P=0.06 for the loss in the injured segment (9 Gy vs. 18 Gy).
Figure 2.
Figure 2. Cumulative Frequency Distribution of the Loss in Minimal Luminal Diameter from Immediately after Angioplasty to Follow-up at Six Months in Patients Treated with Angioplasty and Irradiation with 9, 12, 15, and 18 Gy of Beta Radiation. As uniformly observed with any coronary intervention used in the past, the distribution curve at follow-up after irradiation at the 9-Gy level is shifted to the right, indicating a progressive loss in the initial luminal gain (P<0.001 for the comparison with 0 on the x axis [no change]). However, after irradiation with 18 Gy, the distribution curve is shifted to the left (showing a negative loss), which is indicative of luminal expansion between the postprocedural result and follow-up. The loss curves for the 12-Gy and 15-Gy groups show an intermediate response.
The largest loss in minimal luminal diameter (from the postprocedural result to follow-up) occurred within the irradiated segment of the vessel (Figure 1). Six months after balloon angioplasty, a significant dose-dependent benefit of beta radiation was evident in the minimal luminal diameter (P=0.006 for the comparison of 9 Gy with 18 Gy); the mean diameter for patients who had balloon angioplasty alone was 1.67± 0.09, 1.82±0.13, 1.80±0.11, and 2.10±0.12 mm, respectively (Table 2). The loss in luminal diameter was 0.31±0.08 mm in the 9-Gy group, 0.12±0.09 mm in the 12-Gy group, and 0.09±0.10 mm in the 15-Gy group (Figure 2). After irradiation at the 18-Gy dose, the luminal diameter actually increased by 0.04± 0.10 mm (P=0.008 for the comparison of 9 Gy with 18 Gy). Luminal enlargement occurred in 28 percent, 50 percent, 45 percent, and 74 percent of the patients in the 9-Gy, 12-Gy, 15-Gy, and 18-Gy groups, respectively (P<0.001 for the comparison of 9 Gy with 18 Gy). On follow-up angiographic examination, there was occlusion of the vessel in 4 of the 120 patients who had had balloon angioplasty alone (3.3 percent) and in 7 of the 49 who had also required stents (14.3 percent). Of the patients with occlusion, four (one treated with balloon angioplasty alone and three who received stents) presented with acute symptoms (at 7 days and at 10, 11, and 12 weeks after irradiation). None of these patients were receiving long-term ticlopidine treatment. As a consequence of the absence of ticlopidine therapy, the rates of angiographic restenosis in the patients who required stents were exceedingly high: 30 percent, 33 percent, 15 percent, and 38 percent, respectively (22 percent, 20 percent, 8 percent, and 20 percent, respectively, after the exclusion of the patients with stent thrombosis).
Clinical Results
Table 3.
Table 3. Incidence of Serious Cardiac Events at 210 Days. The incidence of serious cardiac events was within the range of reported values and did not differ significantly among the dose groups (Table 3). The overall incidence of myocardial infarction was 3.3 percent. In addition, three patients had an isolated rise in the creatine phosphokinase level. Repeated percutaneous revascularization of the target vessel was required in 12 percent of the patients treated with balloon angioplasty alone and in 17.6 percent of the patients who required stents.
Discussion
This dose-finding study demonstrates a marked reduction in the rate of restenosis in nonstented arteries after beta-radiation therapy at the 18-Gy level (at a tissue depth of 1 mm). No device or pharmaceutical approach has yielded similarly low rates of restenosis after balloon angioplasty alone. The lowest rate of restenosis reported in the context of a randomized trial was 16 percent at six months with the use of coronary stents,5 which are currently implanted during more than 60 percent of coronary interventions.16 With the use of beta radiation, a restenosis rate of less than 5 percent was achieved in patients who had had good angiographic results after balloon angioplasty alone, suggesting that beta-radiation therapy should be evaluated as a first-line adjunct to angioplasty. The effect observed in our study results from the effect of irradiation on both remodeling and the formation of neointima, as suggested by intravascular ultrasound imaging.17,18
Several systems for endovascular irradiation with sources of gamma or beta radiation have been developed. Gamma radiation was shown to decrease the rates of restenosis after the percutaneous treatment of restenotic lesions, but its effectiveness at the time of the first angioplasty has not been evaluated.19-21 Moreover, the use of gamma radiation is less practical than that of beta radiation in the environment of a catheterization laboratory, because the medical staff must be exposed to greater radiation and the treatment times must be longer.
Results with other systems of beta radiation have not been as encouraging as our results. The initial analysis of the Beta Energy Restenosis Trial (BERT), which used a noncentered strontium-90–yttrium-90 source, found a 15 percent rate of restenosis when the angiographic analysis was limited to the stenotic segment.22 However, more recent reports using either strontium-90–yttrium-90 or phosphorus-32 found higher rates of restenosis (as high as 25 percent) when a longer segment of the vessel was analyzed, as in our study.23
Our data also indicate that caution should be exercised when combining radiation therapy with the implantation of stents. Historically, the occurrence of subacute stent thrombosis was reduced from 25 percent to less than 2 percent when patients received treatment with aspirin and ticlopidine for four weeks after implantation.24-26 After irradiation, there was abrupt thrombosis or late occlusion of vessels in 14.3 percent of patients with stents, a finding that is consistent with other reports.27,28 By delaying endothelialization after the implantation of a stent, radiation therapy may extend the risk of stent thrombosis beyond four weeks. Further studies addressing the safety of combining radiation therapy with stenting are necessary; the long-term use of antiplatelet drugs will presumably be required.
The use of radiation therapy for the treatment of a nonmalignant disease may cause concern about several potential problems. One is radiation-induced arteriopathy, an arterial narrowing that occurs after external fractionated radiation treatment for malignant diseases. This complication occurs after a mean of 16 years, and it occurs more frequently in younger patients in whom large volumes of tissue have been irradiated.29 It is unknown whether this adverse effect can occur several years after the irradiation of a small volume of coronary artery. Another concern is that remodeling of the vessel might ultimately result in the formation of coronary aneurysms. Despite experimental30 and clinical31 evidence that radiation may induce aneurysms, we did not observe this phenomenon. We believe that the aneurysmal dilatations observed in earlier studies were related to high-dose gamma radiation of large volumes of tissue,32 but longer follow-up is certainly warranted.
Another reason for concern is that radiation may induce a soft-tissue sarcoma in the arterial wall or the myocardium. Previous experience with radiation therapy for breast cancer33 suggests that the maximal risk of carcinogenesis during the 10-year period after intravascular radiation therapy is in the range of 1 case per 1 million patients treated, given the small volume of irradiated tissue. Radiation-induced cancers were not found in large groups of patients who had received radiation treatment for keloids or pterygia with focused doses of 12 and 18 Gy.34,35
Our principal findings have important implications for the field of interventional cardiology. Current practice follows the “bigger is better” paradigm, which holds that the bigger the luminal diameter achieved by angioplasty, the better the long-term result.36 A larger lumen can indeed be achieved safely and reliably with the implantation of a stent. In this respect, stents are superior to balloons, although they do not inhibit the neointimal proliferation that causes restenosis. Intracoronary beta radiation has the potential to change this treatment paradigm, not only because it reduces neointimal proliferation but also because of its beneficial effect on the healing process in the arterial wall. In a similar fashion to its effect on the healing surgical wound,37,38 beta radiation decreases chronic arterial constriction and induces luminal enlargement, as we have shown. Further randomized trials should therefore test the clinical efficacy of the combination of beta-radiation therapy and balloon angioplasty, as compared with the implantation of coronary stents, in improving long-term, event-free survival after percutaneous revascularization.
Appendix
Other institutions and investigators that participated in the Dose-Finding Study Group are as follows (the numbers of patients enrolled are given in parentheses): University Hospital, Geneva (57) — I. Papirov, A. Sergey, P. Debruyne, and J. Ramos de Olival; Cardiovascular Center, Onze-Lieve-Vrouw Ziekenhuis, Aalst, Belgium (54) — G. Heyndrickx, L. Verbeke, and J. De Jans; University Hospital, Essen, Germany (26) — M. Haude, D. Flühs, U. Quast, A. Müller, K. Hidgeghty, and C. von Birgelen; University Hospital, Kiel, Germany (22) — M. Thomas, G. Herrmann, R. Wilhelm, and P. Kohl; King's College Hospital, London (22) — N. Lewis; Study Coordination (Boston Scientific) — T. Thaler; Critical Events Committee — J. Dekkers; Angiographic Core Laboratory and Data Analysis — Y. Teunissen, A. Spierings, C. van der Wiel, and G. Kloek.
References (38)
1. Bittl JA. Advances in coronary angioplasty. N Engl J Med 1996;335:1290-1302[Erratum, N Engl J Med 1997;336:670.]
2. Mak KH, Topol EJ. Clinical trials to prevent restenosis after percutaneous coronary revascularization. Ann N Y Acad Sci 1997;811:255-284
3. Serruys PW, de Jaegere P, Kiemeneij F, et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 1994;331:489-495
4. Fischman DL, Leon MB, Baim DS, et al. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994;331:496-501
5. Serruys PW, van Hout B, Bonnier H, et al. Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease. Lancet 1998;352:673-681
6. Wiedermann JG, Marboe C, Amols H, Schwartz A, Weinberger J. Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model. J Am Coll Cardiol 1994;23:1491-1498
7. Verin V, Popowski Y, Urban P, et al. Intraarterial beta irradiation prevents neointimal hyperplasia in a hypercholesterolemic rabbit restenosis model. Circulation 1995;92:2284-2290
8. Waksman R, Robinson KA, Crocker IR, et al. Intracoronary low-dose beta-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model. Circulation 1995;92:3025-3031
9. Waksman R, Rodriguez JC, Robinson KA, et al. Effect of intravascular irradiation on cell proliferation, apoptosis and vascular remodeling after balloon overstretch injury of porcine coronary arteries. Circulation 1997;96:1944-1952
10. Popowski Y, Verin V, Urban P, et al. Intra-arterial yttrium-90 brachytherapy for restenosis prevention. In: Bruggmoser G, Mould RF, eds. Brachytherapy review. Freiburg oncology series monograph no. 1. Freiburg, Germany: Albert-Ludwigs-University, 1994:163-5.
11. Popowski Y, Verin V, Papirov I, et al. High dose rate brachytherapy for prevention of restenosis after percutaneous transluminal coronary angioplasty: preliminary dosimetric tests of a new source presentation. Int J Radiat Oncol Biol Phys 1995;33:211-215
12. Popowski Y, Verin V, Papirov I, et al. Intra-arterial 90-Y brachytherapy: preliminary dosimetric study using a specially modified angioplasty balloon. Int J Radiat Oncol Biol Phys 1995;33:713-717
13. Popowski Y, Verin V, Schwager M, et al. A novel system for intracoronary beta-irradiation: description and dosimetric results. Int J Radiat Oncol Biol Phys 1996;36:923-931
14. Verin V, Urban P, Popowski Y, et al. Feasibility of intracoronary beta-irradiation to reduce restenosis after balloon angioplasty: a clinical pilot study. Circulation 1997;95:1138-1144
15. Sabate M, Costa MA, Kozuma K, et al. Methodological and clinical implications of the relocation of the minimal luminal diameter after intracoronary radiation therapy. J Am Coll Cardiol 2000;36:1536-1541
16. Topol EJ. Coronary-artery stents -- gauging, gorging, and gouging. N Engl J Med 1998;339:1702-1704
17. Meerkin D, Tardif JC, Crocker IR, et al. Effects of intracoronary beta-radiation therapy after coronary angioplasty: an intravascular ultrasound study. Circulation 1999;99:1660-1665
18. Sabate M, Serruys PW, van der Giessen WJ, et al. Geometric vascular remodeling after balloon angioplasty and β-radiation therapy: a three-dimensional intravascular ultrasound study. Circulation 1999;100:1182-1188
19. Teirstein PS, Massullo V, Jani S, et al. Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Engl J Med 1997;336:1697-1703
20. Waksman R, White RL, Chan RC, et al. Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation 2000;101:2165-2171
21. Leon MB, Teirstein PS, Lansky AJ, et al. Intracoronary gamma radiation to reduce in-stent restenosis: the Multicenter Gamma I Randomized Clinical Trial. J Am Coll Cardiol 1999;33:19A-19A abstract.
22. King SB III, Williams DO, Chougule P, et al. Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty: results of the Beta Energy Restenosis Trial (BERT). Circulation 1998;97:2025-2030
23. Raizner AE, Oesterle SN, Waksman R, et al. Inhibition of restenosis with beta-emitting radiotherapy: report of the Proliferation Reduction with Vascular Energy Trial (PREVENT). Circulation 2000;102:951-958
24. Serruys PW, Strauss BH, Beatt KJ, et al. Angiographic follow-up after placement of a self-expanding coronary-artery stent. N Engl J Med 1991;324:13-17
25. Colombo A, Hall P, Nakamura S, et al. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance. Circulation 1995;91:1676-1688
26. Schomig A, Neumann F-J, Kastrati A, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996;334:1084-1089
27. Costa MA, Sabat M, van der Giessen WJ, et al. Late coronary occlusion after intracoronary brachytherapy. Circulation 1999;100:789-792
28. Waksman R, Bhargava B, Mintz GS, et al. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. J Am Coll Cardiol 2000;36:65-68
29. Stewart JR, Fajardo LF, Gillette SM, Constine LS. Radiation injury to the heart. Int J Radiat Oncol Biol Phys 1995;31:1205-1211
30. Gillette EL, Powers BE, McChesney SL, Park RD, Withrow SJ. Response of aorta and branch arteries to experimental intraoperative irradiation. Int J Radiat Oncol Biol Phys 1989;17:1247-1255
31. Condado JA, Waksman R, Gurdiel O, et al. Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans. Circulation 1997;96:727-732
32. Serruys PW, Levendag PC. Intracoronary brachytherapy: the death knell of restenosis or just another episode of a never-ending story? Circulation 1997;96:709-712
33. Taghian A, Vathaire F, Terrier P, et al. Long-term risk of sarcoma following radiation treatment for breast cancer. Int J Radiat Oncol Biol Phys 1991;21:361-367
34. Kovalic JJ, Perez CA. Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys 1989;17:77-80
35. Wilder RB, Buatti JM, Kittelson JM, et al. Pterygium treated with excision and postoperative beta irradiation. Int J Radiat Oncol Biol Phys 1992;23:533-537
36. Kuntz RE, Gibson CM, Nobuyoshi M, Baim DS. Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy. J Am Coll Cardiol 1993;21:15-25
37. Gorodetsky R, McBride WH, Withers HR. Assay of radiation effects in mouse skin as expressed in wound healing. Radiat Res 1988;116:135-144
38. Vegesna V, Withers HR, Holly FE, McBride WH. The effect of local and systemic irradiation on impairment of wound healing in mice. Radiat Res 1993;135:431-433
Citing Articles (182)
Figures/Media
- Table 1. Characteristics of the Patients.
Table 1. Characteristics of the Patients. - Table 2. Angiographic Results Immediately after Balloon Angioplasty and at Six Months.
Table 2. Angiographic Results Immediately after Balloon Angioplasty and at Six Months. - Figure 1. Loss in Minimal Luminal Diameter per Vessel Segment from Immediately after Angioplasty to Follow-up in the 168 Patients for Whom Angiographic Follow-up Data Were Available at Six Months.
Figure 1. Loss in Minimal Luminal Diameter per Vessel Segment from Immediately after Angioplasty to Follow-up in the 168 Patients for Whom Angiographic Follow-up Data Were Available at Six Months. The mean (+SE) loss in minimal luminal diameter is shown for all patients in the four dose groups. The length of the vessel segment analyzed was progressively increased from the obstructed segment to include the injured segment, the irradiated segment plus the edges, and finally to the entire vessel (total). The loss decreased in a dose-dependent manner, and the greatest loss occurred in the irradiated area. P=0.06 for the loss in the injured segment (9 Gy vs. 18 Gy).
- Figure 2. Cumulative Frequency Distribution of the Loss in Minimal Luminal Diameter from Immediately after Angioplasty to Follow-up at Six Months in Patients Treated with Angioplasty and Irradiation with 9, 12, 15, and 18 Gy of Beta Radiation.
Figure 2. Cumulative Frequency Distribution of the Loss in Minimal Luminal Diameter from Immediately after Angioplasty to Follow-up at Six Months in Patients Treated with Angioplasty and Irradiation with 9, 12, 15, and 18 Gy of Beta Radiation. As uniformly observed with any coronary intervention used in the past, the distribution curve at follow-up after irradiation at the 9-Gy level is shifted to the right, indicating a progressive loss in the initial luminal gain (P<0.001 for the comparison with 0 on the x axis [no change]). However, after irradiation with 18 Gy, the distribution curve is shifted to the left (showing a negative loss), which is indicative of luminal expansion between the postprocedural result and follow-up. The loss curves for the 12-Gy and 15-Gy groups show an intermediate response.
- Table 3. Incidence of Serious Cardiac Events at 210 Days.
Table 3. Incidence of Serious Cardiac Events at 210 Days.
