Chromosomal Abnormalities in Non-Hodgkin's Lymphoma

To the Editor: Yunis et al. (April 20 issue)¹ report correlations between specific chromosomal abnormalities and prognosis in non-Hodgkin's lymphomas. We have a number of questions about their observations and conclusions. They report that patients with a duplication of chromosome 2p have a poor prognosis and poor response to chemotherapy regardless of histologic subtype. In contrast, a previous study of cytogenetic abnormality in non-Hodgkin's lymphoma from the same institution furnished evidence that patients with diffuse large-cell immunoblastic lymphomas and a variety of abnormalities in the short arm of chromosome 2 survived longer than patients without these abnormalities.² Moreover, it appears . . .