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Barrett's Esophagus

List of authors.
  • Stuart Jon Spechler, M.D.,
  • and Raj K. Goyal, M.D.

BARRETT'S esophagus is a condition in which the squamous mucosa that normally lines the distal esophagus is replaced by a columnar epithelium resembling that in the stomach and intestines. This aberrant epithelium may be the site of esophageal ulceration, stricture, and adenocarcinoma. Early misconceptions and ongoing controversies regarding the definition, pathogenesis, and clinical features of Barrett's esophagus have resulted in persistent confusion about the disorder. Recent studies have clarified some of these issues substantially. The purpose of this report is to review critically some of the controversies about Barrett's esophagus and to describe the recent advances in our understanding of . . .

Funding and Disclosures

Supported in part by a grant (AM 31092) from the U.S. Public Health Service and a grant {AM 34854) to the Harvard Digestive Disease Center from the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases.

We are indebted to Dr. Ashok Sengupta for the illustrations and to Drs. Wilhelm Doos, Harvey Goldman, Norman Jof Fee, and Robert Riddell for their helpful suggestions.

Author Affiliations

From the Department of Medicine, Division of Gastroenterology, Boston Veterans Administration Medical Center and Boston University School of Medicine; and the Charles A. Dana Research Institute, Department of Medicine, Division of Gastroenterology, Beth Israel Hospital and Harvard Medical School. Boston. Address reprint requests to Dr. Spechler at the Division of Gastroenterology, Boston VA Medical Center. 150 S. Huntington Ave., Boston. MA 02130.

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