Cyclosporine in Refractory Severe Aplastic Anemia

To the Editor: Champlin et al. (Jan. 20, 1983, issue)¹ reported that approximately half their patients with moderate or severe aplastic anemia who were treated with antithymocyte globulin had substantial improvement. The observations that high-dose corticosteroids² and thymostimulin³ are also active in this disease reinforce the concept that immunoregulatory abnormalities have a role in its pathogenesis. We report a case of severe aplastic: anemia that responded to cyclosporine (cyclosporin A), a potent immunosuppressive agent.⁴ A 60-year-old woman was admitted to the hospital in January 1982 for mild anemia and severe thrombocytopenia. She had been quite well before, and there was . . .