Skip to main content
Device Global Header

Subscribe
or Renew

Advanced Search

This article is available to subscribers. Subscribe now. Already have an account? Sign in

Medical IntelligenceFree PreviewArchive

IgG Heavy-Chain (GM) Allotypes and Immune Response to Insulin in Insulin-Requiring Diabetes Mellitus

List of authors.
  • Yoshinobu Nakao, M.D.,
  • Hideo Matsumoto, M.D.,
  • Tokiko Miyazaki, Ph.D.,
  • Nobuhiko Mizuno, M.D.,
  • Naomichi Arima, M.D.,
  • Akemi Wakisaka, M.D.,
  • Kyoko Okimoto, M.D.,
  • Yoshihiro Akazawa, M.D.,
  • Kimiyoshi Tsuji, M.D.,
  • and Takuo Fujita, M.D.

IN guinea pigs1 , 2 and mice, 3 4 5 the ability to develop humoral and cell-mediated immune responses to heterologous insulins is in part controlled by immune-response genes linked to the major histocompatibility complex. In human beings as well, genes in the HLA region play some part in humoral immune reactivity to conventional insulins.6 , 7 However, immunogenetic studies have shown that the immune response has a polygenic basis. At least two different groups of immune-response genes have been demonstrated in human beings and in mice; one is linked to the major histocompatibility complex8 , 9 and the other to the IgG heavy-chain (Gm) gene complex.10 , 11 We have . . .

Funding and Disclosures

Supported in part by a grant for specific diseases from the Japanese Ministry of Health and Welfare.

We are indebted to Miss E. Tanaka and Miss Y. Kiji for their technical assistance, to Ms. U. A. Petralia for her editorial assistance, and to Drs. T. Taminato, S. Kadowaki, M. Koide, and A. Kawa for their valuable clinical assistance and suggestions.

Author Affiliations

From the Second and Third Divisions, Department of Medicine, Kobe University School of Medicine; the Department of Legal Medicine, Osaka Medical College, Osaka; the First Division, Department of Medicine, Kagoshima University School of Medicine, Kagoshima; the Department of Pathology, Hokkaido University School of Medicine, Sapporo; the Third Division, Department of Medicine, Tokyo University School of Medicine, Tokyo; the Department of Medicine, Kyoto National Hospital, Kyoto; and the Department of Transplantation Immunology, Tokai University School of Medicine, Isehara. Address reprint requests to Dr. Nakao at the Third Division, Department of Medicine, Kobe University School of Medicine, 12 Kusunoki-cho 7 Chome, Ikuta-ku, Kobe 650, Japan.

Print Subscriber? Activate your online access.