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Sulfinpyrazone in the Prevention of Cardiac Death after Myocardial Infarction — The Anturane Reinfarction Trial

List of authors.
  • The Anturane Reinfarction Trial Research Group

Abstract

The Anturane Reinfarction Trial is a randomized, double-blind, multicenter clinical trial comparing sulfinpyrazone (200 mg four times a day) and placebo in the prevention of cardiac mortality among patients with a recent documented myocardial infarction. Results represent data accumulated on 1475 eligible patients entered 25 to 35 days after myocardial infarction and followed for an average of 8.4 months. The data reflect excellent randomization, compliance with therapy and tolerance of the drug.

All 69 deaths were of a cardiovascular nature (68 cardiac and one cerebrovascular). For cardiac deaths, the annual death rate was 9.5 per cent in the placebo group and 4.9 per cent in the sulfinpyrazone group, representing an observed reduction of 48.5 per cent (P = 0.018). The annual sudden-cardiac-death rate was 6.3 per cent for the placebo and 2.7 per cent for the sulfinpyrazone group, representing a 57.2 per cent reduction in sudden-cardiac-death rate (P = 0.015). Sulfinpyrazone appears to be effective in reducing cardiac deaths during the first year after myocardial infarction. (N Engl J Med 298:289–295, 1978)

Funding and Disclosures

The Anturane Reinfarction Trial Research Group consists of the following:

Policy Committee: S. Sherry, M.D. (chairman); Prof. M. Gent; A. Lilienfeld, M.D.; M. McGregor, M.D.; F. Mustard, M.D.; P. Yu, M.D.; K. Cartwright, M.D. (ex officio); G. deStevens, Ph.D. (ex officio); and R. A. Ellis, M.D. (ex officio).

Operations Committee: S. H. Kane, M.D. (chairman); E. H. Margulies, Ph.D. (principal monitor); I. A. Chow, Ph.D. (principal biostatistician); S. J. Brewer, M.D.; M. N. Donin, Ph.D.; R. R. Gauch, Ph.D.; L. Leeson, Ph.D.; G. Ohye; P. M. Schutte; F. W. Sedelmaier; and M. Wilhelm, Ph.D.

Audit Committee: A. Lilienfeld, M.D. (chairman); J. E. Grizzle, Ph.D.; and A. L. Johnson, M.D.

EKG Committee: P. Yu, M.D. (chairman); W. S. Frankl, M.D.; and H. F. Warner, M.D.

Editorial Committee: I. A. Chow, Ph.D.; Prof. M. Gent; S. H. Kane, M.D.; E. H. Margulies, Ph.D.; and S. Sherry, M.D.

Statistical Consultant: Prof. J. W. Tukey.

Technical Assistants Group: J. E. Barton; J. Cooper; R. A. Fredrickson; E. M. Gisoldi; M. A. Muslovski; J. O. Reilly; L. D. Vlahakes; and R. H. Williams.

Data Quality Group: (Columbia School of Public Health): D. Rush, M.D.; D. Stuchiner; S. R. Toussie; and A. Wormser.

Principal Investigators and Study Co-ordinators (Clinic Research Centers): M. G. Bourassa, M.D., P. Théroux, M.D., and M. Seguin (Institute of Cardiology, Montreal, PQ, Canada); J. Bray, M.D., and A. Holtzman (Harrisburg Polyclinic Hospital, Harrisburg, PA); M. Broder, M.D., and G. Lutsch (Fairview General Hospital, Cleveland, OH); C. Burton, M.D., and B. Seeley (Toronto General Hospital, Toronto, ON, Canada); T. E. Cuddy, M.D., and J. McManus (Health Sciences Centre, Winnipeg, MB, Canada); C. A. Ellis, Jr., M.D., and P. Costello (Lawrence General Hospital, Lawrence, MA); S. J. Gulotta, M.D., and M. Hurley (North Shore University Hospital, Manhasset, NY); W. P. Hamilton, M.D., L. P. Stickley, Jr., M.D., and B. Sheppers (St. John's Mercy Medical Center, St. Louis, MO); J. A. Horgan, M.D., and L. Harvey (Riverside Hospital, Newport News, VA); J. Hyland, M.D., and V. Long (Baylor University Medical Center, Dallas, TX); J. Kalbfleisch, M.D., and L. Robins (St. Francis Hospital, Tulsa, of); G. A. Klassen, M.D., R. Hooper, M.D., and J. Homan (Royal Victoria Hospital, Montreal, PQ, Canada); H. M. Lowe, M.D., and J. Lowe (Mercy Sacramento Hospital, Sacramento, CA); K. MacMillan, M.D., and J. Bartlett (Hale Hospital, Haverhill, MA); A. Marlon, M.D., and E. MacDonald (Southern Nevada Memorial Hospital, Las Vegas, NV); E. Marcotte, M.D., and G. Nitzchke (Lakeshore General Hospital, Pointe Claire, PQ, Canada); M. Nagel, M.D., and R. Bayduza (Good Samaritan Hospital of Santa Clara Valley, San Jose, CA); J. A. Osborne, M.D., and C. Davies (Vancouver General Hospital, Vancouver, BC, Canada); E. A. Paulk, Jr., M.D., and K. Fowler (DeKalb General Hospital, Decatur, GA); W. A. Pitt, M.D., and K. Hoskinson (Mercy Hospital, San Diego, CA); N. K. Salky, M.D., and S. Goldstein (Baptist Memorial Hospital, Memphis, TN); H. Selinger, M.D., and J. Holstein (Charleston Area Medical Center, Charleston, WV); T. Smitherman, M.D., and B. Bibus (Dallas VA Hospital, Dallas, TX); G. Sweeney, M.D., and M. Callahan (Prince Georges General Hospital, Cheverly, MD); D. R. Taylor, M.D., and M. Heller (Franklin Square Hospital, Baltimore, MD); G. Timmis, M.D., S. Gordon, M.D., N. McLear, and J. Johnson (William Beaumont Hospital, Royal Oak, MI); S. Weinberg, M.D., and C. Supensky (Good Samaritan Hospital, Dayton, OH).

Address reprint requests to Dr. Sol Sherry at the Department of Medicine, Temple University School of Medicine, 3401 N. Broad St., Philadelphia, PA 19140.

We are indebted to Dr. Marvin Zelen, State University of New York at Buffalo, for supplying the Cox model program.

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