Gastrointestinal Absorption of Aluminum from Aluminum-Containing Antacids

Specific tissue burdens of aluminum have been found to be increased in a number of conditions, and evidence has been presented that aluminum may be neurotoxic.^{1 , 2} The source of the aluminum has not been defined. An extensive review of biologic aspects of aluminum found no evidence to support absorption of orally administered aluminum compounds.³ Berlyne et al. indicated that serum aluminum levels did rise in uremic patients who ingested aluminumcycle resins.⁴ However, no definitive studies of changes in plasma and urinary levels in normal persons who ingest aluminum have been reported.Previous attempts to evaluate gastrointestinal absorption of aluminum were . . .