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Recovery of Herpes Simplex Virus from Human Sacral Ganglions

List of authors.
  • J. Richard Baringer, M.D.

HERPES simplex virus is well known for its propensity to cause recurrent oral or genital mucosal infections in man. A variety of clinical observations have suggested that in the interval between overt infections, the virus may reside in neural tissue.1 These circumstances include the frequent occurrence of numbness or tingling before the mucosal eruption, the reliable provocation of oral lesions by surgical manipulation of the trigeminal sensory root,2 and the absence of such lesions in areas previously denervated by section of one or more divisions of the trigeminal nerve.3 Recently, the virus has been recovered from trigeminal ganglions of unselected . . .

Funding and Disclosures

Supported in part by a grant from the National Multiple Sclerosis Society.

* Kindly provided by Dr. E. H. Lennette, chief, Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, CA.

I am indebted to Ms. Irma B. Del Buono, research associate in pediatric diseases, Emory University School of Medicine, Ms. Toni Klassen, and Mr. Fred Grumm for assistance and to Dr. André J. Nahmias for assistance in typing of the viral isolates, and for advice in the course of the study.

Author Affiliations

From the Neurology Research Laboratory, Veterans Administration Hospital, and the Department of Neurology, University of California, San Francisco (address reprint requests to Dr. Baringer at the Neurology Research Laboratory (180), Veterans Administration Hospital, 4150 Clement St., San Francisco, CA 94121).

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