Sulfisoxazole as Chemoprophylaxis for Recurrent Otitis Media — A Double-Blind Crossover Study in Pediatric Practice

ACUTE otitis media is a common problem in pediatric practice. Its incidence in the first decade of life is usually reported to be 10 to 20 episodes per 100 children per year,^{1 , 2} with an even higher incidence in certain high-risk populations.^{3 , 4} The epidemiology of recurrent otitis media has not been extensively studied although the tendency to recurrences is marked, especially among younger children. Approximately half those with otitis during a one-year period will have had at least one previous attack.^{1 , 2} Prospectively, 20 per cent of patients with acute otitis will suffer at least one recurrence in three years.⁵ The main . . .