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The Pulmonary Macrophage in Acute Leukemia

List of authors.
  • David W. Golde, M.D.,
  • Theodore N. Finley, M.D.,
  • and Martin J. Cline, M.D.

Abstract

Because tissue macrophages are generally thought to arise from bone-marrow precursors via the blood monocyte, the question of maintenance of the alveolar macrophage population in bone-marrow failure was examined in three leukemic patients with long sustained monocytopenia. In all three, morphologically and functionally normal alveolar macrophages existed and were capable of producing colony-stimulating activity and of pre-replicative DNA synthesis. These observations indicate that in monocytopenia, the tissue macrophage population persists and may be self-sustaining. (N Engl J Med 290:875–878, 1974)

Funding and Disclosures

Supported by a grant from the California TB and Lung Association, by a grant (CI-60A) from the American Cancer Society, Inc.. and by a grant (CA 12822) from the U.S. Public Health Service.

We are indebted to Mrs. Lisken Byers and Miss Belina Rothman for technical help.

Author Affiliations

From the Division of Hematology-Oncology. Department of Medicine, University of California Center for the Health Sciences, Los Angeles, and the Pulmonary Laboratory, Mount Zion Hospital and Medical Center, San Francisco (address reprint requests to Dr. Golde at the Division of Hematology-Oncology, Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, Cal. 90024).

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