Does Transfer Factor Act Specifically or as an Immunologic Adjuvant?

The excellent study by Bullock, Fields and Brandriss¹ has demonstrated the conversion of lepromatous patients previously skin-test negative to Dharmendra lepromin to positive reactivity after a single treatment with allogeneic lymphocytes or dialyzable transfer factor. The fact that six of the nine recipients in addition showed generalized but transient indurative changes within skin infiltrates suggests that some degree of "reversal" reaction had been produced and offers the possibility that extended treatment with transfer factor would be helpful in terminating the infection or at least in reducing the bacillary load.This and other studies on the effects of transfer factor in . . .