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Acid Rebound

List of authors.
  • John S. Fordtran, M.D.

Abstract

A search for rebound gastric hypersecretion after ingestion of antacids in patients with duodenal ulcer revealed that aluminum-magnesium hydroxide (in a dose of 30 or 60 ml) and sodium bicarbonate (in a dose of 4 or 8 gm) failed to stimulate gastric secretion in the assay system used. By contrast, calcium carbonate (4 or 8 gm) induced gastric hypersecretion.

Detailed studies in one patient suggest that the stimulatory effect of calcium carbonate is mediated by the action of calcium ions within the gastrointestinal tract and that this action is markedly potentiated by food. Although calcium carbonate therapy increases serum calcium concentration, the data suggest that hypercalcemia is not the mechanism by which this antacid stimulates gastric secretion.

Funding and Disclosures

I am indebted to Mr. Verne McDonald for his interest and for the important part he played in these experiments and to Charlotte Douglas for performing the studies.

Author Affiliations

* From the Gastroenterology and Liver Section, Department of Internal Medicine, University of Texas Southwestern Medical School at Dallas (address reprint requests to Dr. Fordtran at the Department of Internal Medicine, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd., Dallas, Tex. 75235).

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