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Acute Otitis Media in Children — Serologic Studies and Attempts to Isolate Viruses and Mycoplasmas from Aspirated Middle-Ear Fluids

List of authors.
  • J. G. Tilles, M.D.†,
  • J. O. Klein, M.D.‡,
  • R. L. Jao, M.D.§,
  • J. E. Haslam, Jr., M.D.,
  • M. Feingold, M.D.∥,
  • S. S. Gellis, M.D.**,
  • and M. Finland, M.D.††

IT has generally been assumed that viruses are involved in the pathogenesis of otitis media either as primary agents or as antecedents of bacterial infections, but neither of these possibilities has been well documented. This report presents the results of attempts to isolate viruses and mycoplasmas from middle-ear fluids obtained by needle aspiration in 90 children with acute otitis media, and results of serologic studies using 18 viral antigens and a Mycoplasma pneumoniae antigen in 73 of these children. The results of bacteriologic studies of the middle-ear fluids, throat and nasopharynx and a discussion of the clinical findings have been . . .

Funding and Disclosures

* From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services and the Pediatric Service, Boston City Hospital, the departments of Medicine and Pediatrics, Harvard Medical School, and the Department of Pediatrics, Boston University School of Medicine (requests for reprints should be addressed to Dr. Finland at the Boston City Hospital, 818 Harrison Avenue, Boston, Massachusetts 02118).

Aided by grants (AI-01695 and T01-AI-00086) from the National Institute of Allergy and Infectious Diseases.

Author Affiliations

BOSTON

† Instructor in medicine, Harvard Medical School; research associate, Thorndike Memorial Laboratory, and clinical assistant, Second and Fourth (Harvard) Medical Services, Boston City Hospital.

‡ Assistant professor of pediatrics, Harvard Medical School; research associate, Thorndike Memorial Laboratory; visiting physician for pediatrics and associate director, Pediatric Service, Boston City Hospital; Career Development Awardee, National Institute of Allergy and Infectious Diseases.

§ Formerly, research fellow in medicine, Harvard Medical School and Thorndike Memorial Laboratory, and clinical fellow, Second and Fourth (Harvard) Medical Services, Boston City Hospital (present address, Department of Medicine, University of the Philippines, Manila).

¶ Formerly, assistant resident in pediatrics, Boston City Hospital.

∥ Assisting physician for pediatrics, Boston City Hospital; assistant professor of pediatrics, Tufts University, School of Medicine; chief, Pediatric Ambulatory Services, New England Medical Center Hospitals.

** Consulting physician for pediatrics, Boston City Hospital; professor of pediatrics and chairman, Department of Pediatrics, Tufts University School of Medicine; Pediatrician-in-chief, New England Medical Center Hospitals.

†† George Richards Minot Professor of Medicine, Harvard University; director, Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital.

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