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Rubella-Virus Hemagglutination-Inhibition Test

List of authors.
  • George L. Stewart, M.D.†,
  • Paul D. Parkman, M.D.‡,
  • Hope E. Hopps§,
  • Robert D. Douglas,
  • Judith P. Hamilton†,
  • and Harry M. Meyer, Jr., M.D.∥

THE isolation of rubella virus1 , 2 in 1961 opened a period of remarkable progress in studies of the virus,3 the disease4 and, recently, experimental vaccines for preventing the disease.5 , 6 Comparable progress has not been made in the development of simple, rapid serodiagnostic methods. Although virus neutralization,7 , 8 fluorescent antibody9 and complement fixation10 are being employed only the complex and time-consuming neutralization test has been capable of furnishing the epidemiologist with fully reliable information regarding rubella immunity.The purpose of this paper is to report specific rubella-virus hemagglutination and the development of a hemagglutination-inhibition test for antibody assay.Materials and MethodsVirus Strains . . .

Funding and Disclosures

* From the Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health, United States Public Health Service.

Author Affiliations

BETHESDA, MARYLAND

† Member, Section on General Virology, Laboratory of Viral Immunology, Division of Biologics Standards.

‡ Chief, Section on General Virology, Laboratory of Viral Immunology, Division of Biologics Standards.

§ Chief, Section on Immunology, Laboratory of Viral Immunology, Division of Biologics Standards.

¶ Member, Section on Immunology, Laboratory of Viral Immunology, Division of Biologics Standards.

∥ Chief, Laboratory of Viral Immunology, Division of Biologics Standards.

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