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Graves's Disease and Total Thyroidectomy — Progression of Severe Eye Changes and Decrease in Serum Long Acting Thyroid Stimulator after Operation

List of authors.
  • Sidney C. Werner, M.D., D.Sc. (MED.)†,
  • Carl R. Feind, M.D.‡,
  • and Mitsuyasu Aida, M.D.§

TOTAL thyroidectomy has been offered as a quick and effective treatment1 , 2 for the severe eye changes of Graves's disease.3 The present study was undertaken to assess the value of this proposed method in patients with evident, active, ocular disease, as well as to determine the effect of thyroid removal upon serum long acting thyroid stimulator (LATS).The natural course of the severe eye changes4 is generally a prolonged one, ending ultimately, and unpredictably, in spontaneous remission. Progression of disease may result in serious damage to vision, to extraocular-muscle function or even to loss of the globes, with threat to life. . . .

Funding and Disclosures

* From the departments of Medicine and Surgery, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital in the City of New York.

Aided by grants (AM-00008 [C17–18]) from the Division of Arthritis and Metabolism, National Institutes of Health.

Author Affiliations

NEW YORK CITY

† Professor of clinical medicine, Columbia University College of Physicians and Surgeons; associate attending physician, Thyroid and Combined Endocrine Clinics, Presbyterian Hospital in the City of New York.

‡ Assistant professor of clinical surgery, Columbia University College of Physicians and Surgeons; associate attending surgeon, Presbyterian Hospital in the City of New York.

§ Research associate in medicine, Presbyterian Hospital in the City of New York.

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