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Suppression of 17-Hydroxycorticosteroids in Plasma and Urine by Single and Divided Doses of Triamcinolone

List of authors.
  • Sylvia D. Grant, M.D.†,
  • Peter H. Forsham, M.D.‡,
  • and Vincent C. DiRaimondo, M.D.§

PROLONGED suppression of the pituitary-adrenal axis after therapy with anti-inflammatory steroids, with resultant decrease in adrenocortical secretion and impaired response to stress, has been the subject of numerous published articles.1 2 3 Di-Raimondo and Forsham,4 , 5 however, reported that less suppression occurs when the total dose of corticosteroid is administered in the morning.In this study we compared the extent and duration of suppression of adrenocortical secretion by 8 mg. of triamcinolone given as a single dose in the morning and by the same amount given in 4 divided doses throughout the day.Materials and MethodsIn a pilot study daily morning doses . . .

Funding and Disclosures

* From the Metabolic Research Unit and the Department of Medicine, University of California School of Medicine, San Francisco.

Some of the studies were done in the General Clinical Research Ward, maintained by a grant (FR-79) from the Division of Research Facilities and Resources, United States Public Health Service.

We are indebted to C. Demos, M.D., of E. R. Squibb and Sons, for the support of this investigation.

Author Affiliations

SAN FRANCISCO

† Trainee in endocrinology and metabolic diseases (Grant T1-AM 5115–08 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service); research fellow, Metabolic Research Unit, University of California Medical Center.

‡ Professor of medicine and pediatrics, University of California School of Medicine; chief of endocrinology and metabolism, Department of Medicine, and director, Metabolic Research Unit, University of California Medical Center.

§ Associate professor of medicine, University of California School of Medicine; associate director, Metabolic Research Unit, University of California Medical Center.

¶ Kindly supplied as Kenacort by E. R. Squibb and Sons, New York City.

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