Skip to main content
Device Global Header

Subscribe
or Renew

Advanced Search

This article is available to subscribers. Subscribe now. Already have an account? Sign in

Original ArticleFree PreviewArchive

Mithramycin in the Treatment of Disseminated Testicular Neoplasms

List of authors.
  • John H. Brown, M.D.†,
  • and B. J. Kennedy, M.D.‡

DISSEMINATED testicular neoplasms other than seminoma have not been effectively controlled by radiologic therapy or chemotherapeutic agents. In an evaluation of these tumors Whitmore1 stated that chemotherapy had no practical value in most cases because of the brevity or incompleteness of the remissions obtained. There were only 5 effective remissions in 100 treated patients. A recently introduced antibiotic, mithramycin, has demonstrated striking antitumor activity in testicular neoplasms, especially the embryonal-cell carcinoma.Except for seminoma, there is a consistently poor prognosis for testicular neoplasms of germinal origin. Dixon and Moore2 reviewed 990 testicular tumors in the United States Army population from . . .

Funding and Disclosures

* From the Department of Internal Medicine, University of Minnesota Medical Center.

Supported by a research grant (CA-03143) from the National Cancer Institute, National Institutes of Health, United States Public Health Service.

We are indebted to Dr. Paul Lober for the pathological review of the microscopical sections of the primary lesion, to Dr. Paul Strandjord for the lactic dehydrogenase determinations and to Miss Kay Newton and Mrs. James Lowman for technical assistance.

Author Affiliations

MINNEAPOLIS, MINNESOTA

† United States Public Health Service senior clinical trainee (CST-103); medical fellow in internal medicine, University of Minnesota Medical Center.

‡ Associate professor of internal medicine, University of Minnesota Medical Center.

Print Subscriber? Activate your online access.