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Pheochromocytoma and Paraganglioma

Hartmut P.H. Neumann, M.D.,
William F. Young, Jr., M.D.,
and Charis Eng, M.D., Ph.D.

Pheochromocytoma and paraganglioma are related tumors that differ mainly in location; pheochromocytomas are adrenal, and paragangliomas can be anywhere else. The symptoms are protean and common, but the tumors are rare. The diagnosis may signify an underlying genetic syndrome.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

No potential conflict of interest relevant to this article was reported.

This article was updated on August 8, 2019, at NEJM.org.

We thank Tobias Krauss, M.D., Juri Ruf, M.D., Stephan Meckel, M.D., and Martin Walz, M.D., for providing clinical, radiographic, and histologic images; and Giuseppe Opocher, M.D., Francesca Schiavi, Ph.D., and Birke Bausch, M.D., for providing genetic data presented graphically.

Author Affiliations

From the Section for Preventive Medicine, Medical Center–University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany (H.P.H.N.); the Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN (W.F.Y.); and the Genomic Medicine Institute, Lerner Research Institute, and Taussig Cancer Institute, Cleveland Clinic, Cleveland (C.E.).

Address reprint requests to Dr. Neumann at the Section for Preventive Medicine, Faculty of Medicine, Albert-Ludwigs-University, 79104 Freiburg, Germany, or at [email protected].

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