Skip to main content
Device Global Header

Subscribe
or Renew

Advanced Search

This article is available to subscribers. Subscribe now. Already have an account? Sign in

Review Article

Graves’ Disease

List of authors.
  • Terry J. Smith, M.D.,
  • and Laszlo Hegedüs, M.D., D.M.Sc.

Graves' disease is an autoimmune disorder in which the thyroid is activated by antibodies to the thyrotropin receptor. The hyperthyroidism that develops is one of many somatic and psychiatric manifestations of the disease that can affect the quality and length of life.

Continue reading this article

Select an option below:

Create your account to get 2 free subscriber-only articles each month.

Get Free Access Now Subscribe For Full Access

Already have an account?

Sign In

Print subscriber?

Activate your online access.

Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Smith reports holding patents related to the detection of antibody-mediated inflammatory auto-immune disorders (US 6936426), the diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders (US 7998681 and US 8153121), and diagnostic methods related to Graves’ disease and other autoimmune disorders (US 8178304). No other potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, and the Department of Internal Medicine, University of Michigan Medical School — both in Ann Arbor (T.J.S.); and the Departments of Endocrinology and Metabolism (L.H.) and Ophthalmology (T.J.S.), Odense University Hospital, University of Southern Denmark, Odense.

Address reprint requests to Dr. Smith at the Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Brehm Tower, 1000 Wall St., Ann Arbor, MI 48105, or at .

Print Subscriber? Activate your online access.