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Review Article

Acute Myeloid Leukemia

List of authors.
  • Hartmut Döhner, M.D.,
  • Daniel J. Weisdorf, M.D.,
  • and Clara D. Bloomfield, M.D.

Many recent biologic insights have shed light on the nosology of acute myeloid leukemia. Although this new knowledge has not yet had a major influence on the treatment of the disease, strategies under investigation may improve outcomes.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Döhner reports receiving fees for serving on advisory boards from Celgene, Astellas, Eli Lilly, Bristol-Myers Squibb, GlaxoSmithKline, Astex Pharmaceuticals, Roche, Celator Pharmaceuticals, Agios Pharmaceuticals, Seattle Genetics, Tolero Pharmaceuticals, Sunesis Pharmaceuticals, and Amgen, honoraria for scientific presentations from Celgene, and fees for chairing a symposium from Amgen; and Dr. Weisdorf, receiving consulting fees from Alexion, Amgen, and Pharmacyclics, honoraria for study planning from Pharmacyclics and Enlivex Therapeutics, lecture fees from Therakos, travel support from Millennium, and grant support from Alexion. No other potential conflict of interest relevant to this article was reported.

We thank Dr. Lars Bullinger for assistance with an earlier version of Figure 1.

Author Affiliations

From the Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany (H.D.); the Blood and Marrow Transplant Program, University of Minnesota, Minneapolis (D.J.W.); and the Ohio State University Comprehensive Cancer Center, Columbus (C.D.B.).

Address reprint requests to Dr. Bloomfield at the Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute C933, 460 W. 10th Ave., Columbus, OH 43210, or at .

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