The four main types of inflammatory muscle disease — dermatomyositis, polymyositis, necrotizing autoimmune myositis, and inclusion-body myositis — are summarized. Pathogenesis, differential diagnosis, and treatment approaches are discussed.
Funding and Disclosures
Disclosure forms provided by the author are available with the full text of this article at NEJM.org.
Dr. Dalakas reports having served on a data and safety monitoring board for Baxter, serving on steering committees for Grifols/Talecris, Novartis, and Servier, and receiving consulting fees from Baxter, Therapath Laboratory, CSL Behring, and Genzyme and lecture fees from Baxter and Octapharma. No other potential conflict of interest relevant to this article was reported.
I thank all the clinical and research fellows who participated in my studies over many years, the numerous clinicians and scientists for their enormous contributions to the field, and all the patients who participated in my research and continue to teach me about these diseases.
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