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Review ArticleMechanisms of Disease

Mendelian Disorders of Membrane Trafficking

List of authors.
  • Maria Antonietta De Matteis, M.D.,
  • and Alberto Luini, M.D.

These disorders have taught us about the processes involved in packaging proteins for secretion. Though the disorders are rare, they shed light on processes that are thought to be involved in common diseases, such as Alzheimer's disease and type 2 diabetes.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

We thank Giovanni D'Angelo for many important discussions; Brunella Franco, Sandro Banfi, Daniela Corda, and Nicola Brunetti for their critical reading of the manuscript; and C.P. Berrie for editorial assistance.

Author Affiliations

From the Telethon Institute of Genetics and Medicine (M.A.D.M., A.L.) and the Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche (A.L.) — both in Naples, Italy; and Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy (M.A.D.M.).

Address reprint requests to Dr. De Matteis at the Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy, or at .

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