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Review ArticleCurrent Concepts

Diagnosis from the Blood Smear

List of authors.
  • Barbara J. Bain, F.R.A.C.P., F.R.C.Path.

An examination of the blood smear (or film) may be requested by physicians or initiated by laboratory staff. With the development of sophisticated automated blood-cell analyzers, the proportion of blood-count samples that require a blood smear has steadily diminished and in many clinical settings is now 10 to 15 percent or less. Nevertheless, the blood smear remains a crucial diagnostic aid. The proportion of requests for a complete blood count that generate a blood smear is determined by local policies and sometimes by financial and regulatory as well as medical considerations. For maximal information to be derived from a blood . . .

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Funding and Disclosures

A related slide show is available at www.nejm.org.

I am indebted to Dr. Bernadette Garvey of Toronto and Dr. LoAnne Peterson of Chicago for their helpful comments on the manuscript.

Author Affiliations

From the Department of Haematology, St. Mary's Hospital, London.

Send reprint requests to Dr. Bain at St. Mary's Hospital, Praed St., London W2 1NY, United Kingdom, or at .

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