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Evidence from Pragmatic Trials during Routine Care — Slouching toward a Learning Health System

List of authors.
  • Gregory E. Simon, M.D., M.P.H.,
  • Richard Platt, M.D.,
  • and Adrian F. Hernandez, M.D., M.H.S.

Pragmatic clinical trials involving random treatment assignment embedded in everyday practice aim to efficiently generate relevant and valid evidence regarding real-world treatment decisions. Such trials often face barriers, but steps can be taken to facilitate them.

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Funding and Disclosures

Disclosure forms provided by the authors are available at

Author Affiliations

From Kaiser Permanente Washington Health Research Institute, Seattle (G.E.S.); the Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston (R.P.); and Duke University School of Medicine, Durham, NC (A.F.H.).

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