Supported by AstraZeneca.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
Dr. McMurray reports receiving fees (all fees listed paid to Glasgow University) for serving on a steering committee from Bayer, fees for serving on a steering committee, fees for serving on an end-point committee, and travel support from Cardiorentis, fees for serving on a steering committee and travel support from Amgen, fees for serving on a steering committee and travel support from Oxford University–Bayer, fees for serving as principal investigator of a trial and travel support from Theracos, fees for serving on a steering committee and travel support from AbbVie, fees for serving on a steering committee from DalCor Pharmaceuticals, fees for serving on a data and safety monitoring committee from Pfizer, fees for serving on a data and safety monitoring committee from Merck, fees for serving on an executive committee, fees for serving as co-principal investigator of a trial, fees for serving on a steering committee, fees for serving on an executive committee, travel support, and advisory board fees from Novartis, fees for serving as co-principal investigator for a trial, fees for serving on a steering committee, and travel support from GlaxoSmithKline, fees for serving on a steering committee from Bristol-Myers Squibb, and fees for serving on a steering committee, fees for serving on an end-point adjudication committee, and travel support from Vifor Pharma–Fresenius; Dr. Solomon, receiving grant support and consulting fees (all fees listed paid to Brigham and Women’s Hospital) from Alnylam Pharmaceuticals, Amgen, AstraZeneca, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, MyoKardia, Novartis, Theracos, Bayer, and Cytokinetics, grant support from Bellerophon Therapeutics, Celladon, Ionis Pharmaceuticals, Lonestar Heart, Mesoblast, Sanofi Pasteur, and Eidos Therapeutics, consulting fees from Akros Pharma, Corvia Medical, Ironwood Pharma, Merck, Roche, Takeda Pharmaceutical, Quantum Genomics, AOBiome, Cardiac Dimensions, Tenaya Therapeutics, and Daiichi Sankyo, and fees for serving on a data and safety monitoring board from Janssen; Dr. Inzucchi, receiving advisory fees from AstraZeneca and Zafgen, lecture fees, consulting fees, fees for serving as a clinical-trial publications committee member, reimbursement for medical writing, and travel support from Boehringer Ingelheim, fees for serving on a steering committee and travel support from Sanofi–Lexicon, lecture fees, consulting fees, and travel support from Merck, and advisory fees and travel support from vTv Therapeutics and Abbott–Alere; Dr. Køber, receiving lecture fees from Novartis and Bristol-Myers Squibb; Dr. Kosiborod, receiving grant support, honoraria, and research support from AstraZeneca, grant support and honoraria from Boehringer Ingelheim, and honoraria from Sanofi, Amgen, Novo Nordisk, Merck (Diabetes), Eisai, Janssen, Bayer, GlaxoSmithKline, Glytec, Intarcia Therapeutics, Novartis, Applied Therapeutics, Amarin, and Eli Lilly; Dr. Ponikowski, receiving consulting fees, fees for serving on a speakers bureau, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Boehringer Ingelheim, lecture fees from Pfizer, fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Amgen, grant support (paid to his institution), fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Vifor Pharma, fees for serving on a speakers bureau and consulting fees from Servier, fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Bayer, fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Bristol-Myers Squibb, fees for serving on a speakers bureau and consulting fees from Respicardia, fees for serving on a speakers bureau from Berlin-Chemie, fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Cibiem, fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from Novartis, and fees for serving on a speakers bureau, consulting fees, and fees (paid to himself and to his institution) for serving as an investigator and steering or executive committee member for clinical trials from RenalGuard; Dr. Sabatine, receiving grant support (paid to Brigham and Women’s Hospital) and consulting fees from Amgen, AstraZeneca, Intarcia Therapeutics, Janssen Research and Development, the Medicines Company, MedImmune, Merck, and Novartis, receiving consulting fees from Anthos Therapeutics, Bristol-Myers Squibb, CVS Caremark, DalCor Pharmaceuticals, Dyrnamix, Esperion, IFM Therapeutics, and Ionis Pharmaceuticals, receiving grant support (paid to Brigham and Woman’s Hospital) from Bayer, Daiichi Sankyo, Eisai, GlaxoSmithKline, Pfizer, Poxel, Quark Pharmaceuticals, and Takeda Pharmaceutical, and serving as a member of the TIMI Study Group, which receives grant support (paid to Brigham and Women’s Hospital) from Abbott, Aralez Pharmaceuticals, Roche, and Zora Biosciences; Dr. Anand, receiving fees for serving as United States national leader of a trial from AstraZeneca, fees for serving on a steering committee from ARCA Biopharma, Amgen, LivaNova, and Novartis, fees for serving on an end-point committee from Boehringer Ingelheim, fees for serving as chair of a data and safety monitoring board from Boston Scientific, and advisory board fees from Zensun; Dr. Bělohlávek, receiving advisory board fees from Novartis and Pfizer and lecture fees from Getginge; Dr. Böhm, receiving lecture fees from Amgen, Bayer, Servier, Medtronic, Boehringer Ingelheim, Vifor Pharma, and Bristol-Myers Squibb, grant support and lecture fees from AstraZeneca, and grant support from Deutsche Forschungsgemeinschaft; Dr. Chiang, receiving honoraria from AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi Sankyo, MSD, Novartis, Pfizer, and Sanofi; Dr. de Boer, receiving grant support (paid to University Medical Center Groningen [UMCG]), consulting fees, and lecture fees from AstraZeneca, grant support (paid to UMCG) from Bristol-Myers Squibb, grant support (paid to UMCG) and consulting fees from Abbott, grant support (paid to UMCG) and lecture fees from Roche, and consulting fees from MandalMed and being a minority shareholder in scPharmaceuticals; Dr. Desai, receiving consulting fees from Abbott, Biofourmis, Boston Scientific, Boehringer Ingelheim, DalCor Pharmaceuticals, and Regeneron, grant support (paid to Brigham and Women’s Hospital) and consulting fees from Alnylam Pharmaceuticals and Novartis, and advisory board fees from Corvidia and Relypsa; Dr. Howlett, receiving grant support, consulting fees, and lecture fees from AstraZeneca, Boehringer Ingelheim, Novartis, and Servier, consulting fees and lecture fees from Novo Nordisk, consulting fees from Janssen, and grant support, consulting fees, lecture fees, and provision of drugs from Pfizer; Dr. Katova, receiving fees for serving as national coordinator of a trial from Novartis and AstraZeneca; Dr. Kitakaze, receiving grant support and lecture fees from Astellas Pharma, Sanofi, Pfizer, Ono Pharmaceutical, Novartis, and Mitsubishi Tanabe Pharma, lecture fees from Daiichi Sankyo, Bayer, Boehringer Ingelheim, Kowa Pharmaceutical, Sawai Pharmaceutical, MSD, Shionogi, Kureha, Taisho Toyama Pharmaceutical, Takeda Pharmaceutical, and Toa Eiyo, and manuscript fees from Japan Medical Data Center; Dr. Ljungman, receiving lecture fees and advisory board fees from AstraZeneca, lecture fees from Novartis, and advisory board fees from Pfizer; Dr. Merkely, receiving lecture fees from AstraZeneca, Sanofi Aventis, Servier, and Biotronik and grant support and lecture fees from Abbott and Medtronic; Dr. Nicolau, receiving consulting fees from Amgen, grant support from AstraZeneca, Bristol-Myers Squibb, CSL Behring, DalCor Pharmaceuticals, Janssen, Novo Nordisk, and Vifor Pharma, grant support and fees for serving as principal investigator from Bayer, lecture fees from Daiichi Sankyo, grant support and consulting fees from Novartis, grant support, fees for serving as principal investigator, and advisory board fees from Sanofi, and lecture fees and advisory board fees from Servier; Dr. O’Meara, receiving fees for serving on a clinical trial (paid to her institution), consulting fees, and lecture fees from AstraZeneca, Bayer, Amgen, and Novartis, consulting fees from Merck, fees for serving on a clinical trial (paid to her institution) from American Regent, and consulting fees and lecture fees from Pfizer and Boehringer Ingelheim; Dr. Petrie, receiving lecture fees from AstraZeneca, Novartis, and Eli Lilly, grant support, advisory board fees, and fees for serving on an end-point committee from Boehringer Ingelheim, advisory board fees, lecture fees, and fees for serving on an end-point committee from Novo Nordisk, advisory board fees from Napp Pharmaceuticals, and fees for serving on an end-point committee from Takeda Pharmaceutical and Bayer; Dr. Tereshchenko, receiving lecture fees from Servier, Pfizer, Novartis, and Boehringer Ingelheim; Dr. Verma, receiving grant support, lecture fees, and advisory board fees from AstraZeneca, Boehringer Ingelheim, Bayer, Janssen, and Merck, lecture fees from Sun Pharmaceutical Industries and EOCI Pharmacomm, grant support and advisory board fees from Amgen, and lecture fees and advisory board fees from Sanofi and Eli Lilly; Dr. Held, receiving grant support, advisory board fees, and lecture fees from Bayer, grant support and advisory board fees from Boehringer Ingelheim, grant support from Bristol-Myers Squibb, advisory board fees from Coala Life, and fees for serving on a data and safety monitoring board (paid to his institution) from Idorsia; Dr. DeMets, receiving consulting fees from Frontier Science, Actelion, Bristol-Myers Squibb, Medtronic, Boston Scientific, GlaxoSmithKline, and Merck, and consulting fees and being owner of DL DeMets Consulting; Dr. Docherty, receiving grant support from Novartis; Dr. Jhund, receiving consulting fees, advisory board fees, and lecture fees from Novartis, advisory board fees from Cytokinetics, and grant support from Boehringer Ingelheim; Drs. Bengtsson and Sjöstrand, being employed by AstraZeneca; and Dr. Langkilde, being employed by and holding shares in AstraZeneca. No other potential conflict of interest relevant to this article was reported.
This article was published on September 19, 2019, at NEJM.org.
A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.
