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Clinical Therapeutics

Psoralen and Ultraviolet A Light Therapy for Psoriasis

List of authors.
  • Robert S. Stern, M.D.

A 52-year-old man with psoriasis seeks treatment for his skin condition. Treatment with psoralen and ultraviolet A (PUVA) is recommended. PUVA has been used since the 1970s for the treatment of psoriasis, although few randomized studies and clinical trials comparing this treatment with no treatment or with other forms of treatment have been conducted. PUVA therapy increases the risks of both nonmelanoma skin cancer and melanoma.

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Funding and Disclosures

Supported by a contract from the National Institutes of Health (N01AR02246).

No potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Department of Dermatology, Harvard Medical School, and Beth Israel Deaconess Medical Center — both in Boston.

Address reprint requests to Dr. Stern at the Department of Dermatology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, or at .

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