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Correspondence

Enterovirus D68 in the Anterior Horn Cells of a Child with Acute Flaccid Myelitis

Autopsy material from a child who died from an acute flaccid myelitis–like illness showed EV-D68 RNA and protein in anterior horn cells and their axons, strongly implicating the virus as the cause of the disorder.

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Matthew R. Vogt, M.D., Ph.D.
University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC

Peter F. Wright, M.D.
William F. Hickey, M.D.
Dartmouth Hitchcock Medical Center, Lebanon, NH

Tristan De Buysscher, B.A.
University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC

Kelli L. Boyd, D.V.M., Ph.D.
James E. Crowe, Jr., M.D.
Vanderbilt University Medical Center, Nashville, TN

Funding and Disclosures

Supported by a grant from the National Institute of Allergy and Infectious Diseases (K08 AI153125) and the Pediatric Infectious Diseases Society–St. Jude Children’s Hospital Fellowship Program in Basic Research to Dr. Vogt, with the fellowship funded by St. Jude Children’s Research Hospital and jointly sponsored by the Pediatric Infectious Diseases Society and St. Jude Children’s Research Hospital; a grant from the National Institute of Allergy and Infectious Diseases (U19 AI117905) to Dr. Crowe; a grant from the National Cancer Institute (5P30 CA68485-19) to the Vanderbilt Translational Pathology Shared Resource (TPSR) for the performance of histology experiments; and a Shared Instrumentation Grant (S10 OD023475-01A1) from the National Institutes of Health Office of the Director to the TPSR for the Leica Bond RX. The University of North Carolina Bioinformatics and Analytics Research Collaborative, which is supported by a University of North Carolina at Chapel Hill School of Medicine strategic fund, performed statistical analyses.

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

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