Cannabinoids in the Treatment of Epilepsy

To the Editor: The need for effective antiseizure drugs in addition to available compounds is obvious. The review article by Friedman and Devinsky (Sept. 10 issue)¹ highlights experimental data that suggest antiseizure effects of cannabinoids. However, the overview of studies indicating that cannabinoids can also provoke seizures seems incomplete, since studies examining the effects of recreational use of cannabis and other studies suggest serious adverse effects, including clinically significant drug–drug interactions, in patients who have epilepsy with or without underlying conditions.²⁵I agree that data are lacking from well-controlled clinical trials on the antiseizure properties of cannabinoids. However, it . . .