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Review ArticleAdvances in Immunology

T-Cell Function and Migration — Two Sides of the Same Coin

List of authors.
  • Ulrich H. von Andrian, M.D., Ph.D.,
  • and Charles R. Mackay, Ph.D.

Since the pioneering work of Gowans and colleagues in the 1960s,1,2 much progress has been made in understanding the pivotal role of cell migration in immunity. We now have considerable knowledge of the way in which specialized leukocytes are channeled to distinct target tissues in immune responses and inflammation (Figure 1). This review will concentrate on the migration of T cells, which are at the heart of most adaptive immune responses.Since T cells respond to pathogens only on direct contact with pathogen-derived antigen, they must migrate to sites where antigen is found. The T-cell receptor recognizes a peptide . . .

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Funding and Disclosures

Supported by grants from the National Institutes of Health (to Dr. von Andrian), the Glazebrook Trust, and the CRC for Asthma (to Dr. Mackay).

We are indebted to the members of Dr. von Andrian's laboratory for critical reading and comments.

Author Affiliations

From the Center for Blood Research, Department of Pathology, Harvard Medical School, Boston (U.H.A.); and the Garvan Institute of Medical Research, Darlinghurst, N.S.W., Australia (C.R.M.).

Address reprint requests to Dr. von Andrian at the Center for Blood Research, 200 Longwood Ave., Boston, MA 02115, or at .

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