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Review ArticleMechanisms of Disease

Acute-Phase Proteins and Other Systemic Responses to Inflammation

List of authors.
  • Cem Gabay, M.D.,
  • and Irving Kushner, M.D.

A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation. In 1930 interest was focused on these changes by the discovery of C-reactive protein (so named because it reacted with the pneumococcal C-polysaccharide) in the plasma of patients during the acute phase of pneumococcal pneumonia.1 Accordingly, these systemic changes have since been referred to as the acute-phase response,2 even though they accompany both acute and chronic inflammatory disorders. New acute-phase phenomena continue to be recognized, and the mechanisms mediating them are becoming better understood. This review summarizes much of . . .

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Funding and Disclosures

Supported by a grant (AG 02467) from the National Institutes of Health (to Dr. Kushner) and a postdoctoral fellowship grant from the Swiss National Foundation for Scientific Research and the Fondation Suisse de Bourse de Médecine et Biologie (to Dr. Gabay).

We are indebted to Drs. John W. Harris, William P. Arend, Barbara Barna, M. Asim Khan, and Mojtaba Youssefi for critical reviews of the manuscript, to Dr. Carl Grunfeld for useful conversations, and to Ms. Debra Rzewnicki for editorial assistance.

Author Affiliations

From the Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver (C.G.); and the Departments of Medicine and Pathology and the Rammelkamp Center for Research, Case Western Reserve University, MetroHealth Campus, Cleveland (I.K.).

Address reprint requests to Dr. Kushner at the Department of Medicine, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109-1998, or at .

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