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Review ArticleMechanisms of Disease

Atherosclerosis — An Inflammatory Disease

List of authors.
  • Russell Ross, Ph.D.

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis,1 the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .

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Funding and Disclosures

Supported in part by a grant (HL18645) from the National Institutes of Health.

I am indebted to all the fellows, students, and assistants who have worked with me over the years, in particular to Elaine Raines for her support and scientific endeavors and for her critical reading of the manuscript; to Dr. David Hajjar, Dr. Goran Hansson, Dr. Samuel Wright, and Dr. Momtaz Wassef for their review and suggestions; and to Barbara Droker for assistance in preparing the manuscript.

Author Affiliations

From the Department of Pathology, University of Washington School of Medicine, Box 357470, Seattle, WA 98195-7470, where reprint requests should be addressed to Dr. Ross (e-mail: ).

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