Skip to main content
Device Global Header

Subscribe
or Renew

Advanced Search

This article is available to subscribers. Subscribe now. Already have an account? Sign in

Review ArticleMechanisms of Disease

Molecular Pathogenesis of Cholestasis

List of authors.
  • Michael Trauner, M.D.,
  • Peter J. Meier, M.D.,
  • and James L. Boyer, M.D.

The formation of bile is a vital function, and its impairment by drugs or infectious, autoimmune, metabolic, or genetic disorders results in the syndrome commonly known as cholestasis.1 The secretion of bile normally depends on the function of a number of membrane transport systems in hepatocytes and bile-duct epithelial cells (cholangiocytes) and on the structural and functional integrity of the bile-secretory apparatus. This review summarizes the molecular defects in hepatocellular membrane transporters that are associated with various forms of cholestatic liver disease in humans.Molecular Mechanisms of Bile FormationBile formation is an osmotic secretory process that is driven by . . .

Continue reading this article

Select an option below:

Create your account to get 2 free subscriber-only articles each month.

Get Free Access Now Subscribe For Full Access

Already have an account?

Sign In

Print subscriber?

Activate your online access.

Author Affiliations

From the Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Graz, Austria (M.T.); the Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland (P.J.M.); and the Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, Conn. (J.L.B.).

Address reprint requests to Dr. Boyer at the Yale University School of Medicine, P.O. Box 208109, New Haven, CT 06520-8019.

Print Subscriber? Activate your online access.